MUC1可用于预测间皮瘤 - 生物谷

作者：yangtao 来源：生物谷 2013-9-6 21:11:57

关键词：MUC1,间皮瘤,生物标记物

2013年9月6日讯 /生物谷BIOON/ --一项由澳大利亚研究人员主导的研究发现，一种名为MUC1的糖蛋白可能被用来诊断或者预测间皮瘤。间皮瘤是一种罕见癌症，主要是由于接触石棉等致癌物质而导致。研究人员发现MUC1蛋白的异常过量表达和这种癌症的爆发存在直接联系。研究人员表示通过开发以MUC1为靶点的检测方法或者药物，或可预测并治疗这种罕见癌症。（生物谷Bioon.com）

详细英文报道：

A new Australian study showed that the glycoprotein MUC1 is overexpressed in peritoneal mesothelioma, a rare abdominal cancer caused by exposure to asbestos, and could serve as a prognostic tool in determining the severity of the deadly disease.

Researchers at the University of New South Wales tested 42 peritoneal mesothelioma patients for the overexpression of MUC1, a mucin protein that staves off infection by preventing pathogens from entering cells. Of those patients in the study, 38 of them, or 90%, showed an overabundance of the protein. The team found that it was this high level of MUC1--as well as being older than 60 at the time of diagnosis--that led to poor outcomes.

"MUC1 evaluation by immunohistochemistry may serve as a useful prognostic tool in malignant peritoneal mesothelioma, but may need further confirmation in larger patients' cohort," the authors wrote in their findings published in the International Journal of Biological Markers.

Mesothelioma is most commonly associated with the lungs as a result of working with asbestos, but peritoneal mesothelioma affects the lining of the abdomen and accounts for about 25% to 30% of mesothelioma cases.

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